732 Ceramide synthase 4 controls epidermal lipid composition and barrier function
نویسندگان
چکیده
منابع مشابه
The role of ceramide composition in the lipid organisation of the skin barrier.
The lipid lamellae in the stratum corneum (SC) play a key role in the barrier function of the skin. The major lipids are ceramides (CER), cholesterol (CHOL) and free fatty acids (FFA). In pig SC at least six subclasses of ceramides (referred to as CER 1, 2-6) are present. Recently it was shown that in mixtures of isolated pig SC ceramides (referred to as CER(1-6)) and CHOL two lamellar phases a...
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The stratum corneum as the outermost epidermal layer protects against exsiccation and infection. Both the underlying cornified envelope (CE) and the intercellular lipid matrix contribute essentially to these two main protective barriers. Epidermis-unique ceramides with ultra-long-chain acyl moities (ULC-Cers) are key components of extracellular lipid lamellae (ELL) and are bound to CE proteins,...
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The authors inadvertently omitted Preethi Vijayaraj from the list of authors. The corrected author list appears above. Her affiliation is Translational Centre for Regenerative Medicine Leipzig and Institute of Biology, Division of Cell and Developmental Biology, University of Leipzig, 04103 Leipzig, Germany. Her present address is Department of Pediatrics, University of California, Los Angeles,...
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Keratin intermediate filaments (KIFs) protect the epidermis against mechanical force, support strong adhesion, help barrier formation, and regulate growth. The mechanisms by which type I and II keratins contribute to these functions remain incompletely understood. Here, we report that mice lacking all type I or type II keratins display severe barrier defects and fragile skin, leading to perinat...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2018
ISSN: 0022-202X
DOI: 10.1016/j.jid.2018.03.741